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Valium is the brand name of the generic drug diazepam, which is a benzodiazepine. Benzodiazepines are sedative-hypnotic drugs and central nervous system (CNS) depressants. Valium initially debuted on the market in 1963, and for nearly 15 years, it ranked as the best-selling drug in America. Today there are more than 500 generic brands of Valium sold in a variety of tablets and other formulations.3 Valium and other benzodiazepines (commonly referred to as “benzos”) decrease excitation in the brain, or slow brain activity, through interactions with the gamma-aminobutyric acid (GABA) receptor.4 Other commonly prescribed benzodiazepines that function similarly include